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PDE5-IN-3

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Catalog No. T62681Cas No. 2538149-57-2

PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.

PDE5-IN-3

PDE5-IN-3

😃Good
Catalog No. T62681Cas No. 2538149-57-2
PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.
Pack SizePriceAvailabilityQuantity
25 mg$1,520 6-8 weeks
50 mg$1,980 6-8 weeks
100 mg$2,500 6-8 weeks
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Product Introduction

Bioactivity
Description
PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.
Chemical Properties
Molecular Weight448.27
FormulaC21H14BrN5O2
Cas No.2538149-57-2
Storage & Solubility Information
StorageShipping with blue ice.

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