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PEG4-bis(phosphonic acid diethyl ester)

Name: PEG4-bis(phosphonic acid diethyl ester)
Brand: TargetMol
SKU: T16458
Rating: 4.5 (1 reviews)

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Catalog No. T16458Cas No. 106338-06-1

PEG4-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative functioning as a linker in PROTAC synthesis, specifically designed for creating proteolysis-targeting chimeras (PROTACs)[1].

PEG4-bis(phosphonic acid diethyl ester)

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Catalog No. T16458Cas No. 106338-06-1

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Product Introduction

Bioactivity

Description	PEG4-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative functioning as a linker in PROTAC synthesis, specifically designed for creating proteolysis-targeting chimeras (PROTACs)[1].
In vitro	PROTACs consist of two distinct ligands linked by a connector: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade these target proteins[1].

Chemical Properties

Molecular Weight	466.4
Formula	C₁₆H₃₆O₁₁P₂
Cas No.	106338-06-1
Relative Density.	1.176 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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