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Pelecopan

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Pelecopan

Catalog No. T62020Cas No. 2378380-49-3

Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D (IC50=14.3 nM) that prevents both intravascular and extravascular hemolysis in PNH.

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Pack Size	Price	Availability
25 mg	$1,520	10-14 weeks
50 mg	$1,980	10-14 weeks
100 mg	$2,500	10-14 weeks

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Product Introduction

Bioactivity

Description

Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D (IC50=14.3 nM) that prevents both intravascular and extravascular hemolysis in PNH.

In vitro

BCX9930 has a potent, highly specific inhibitory activity for purified human factor D with an IC 50 value of 14.3 nM and also inhibits its proteolytic activity against factor B bound to C3b with an IC 50 of 28.1 nM. BCX9930 completely blocks hemolysis of PNH cells in vitro (with an IC 50 value of 29.5 nM in rabbit erythrocytes) and suppresses the accumulation of C3 fragments on PNH erythrocytes. BCX9930 suppresses AP activity in rhesus monkeys ex vivo assays [1] [3].

Chemical Properties

Molecular Weight	406.41
Formula	C23H19FN2O4
Cas No.	2378380-49-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc