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Pep63, a neuroprotective peptide (VFQVRARTVA), enhances synaptic plasticity and memory. It competitively binds with Aβ1-42 oligomers, thereby inhibiting the formation of Aβ fibrils. Pep63 is employed in research focused on Alzheimer's disease (AD).
Pack Size | Price | Availability | Quantity |
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10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Pep63, a neuroprotective peptide (VFQVRARTVA), enhances synaptic plasticity and memory. It competitively binds with Aβ1-42 oligomers, thereby inhibiting the formation of Aβ fibrils. Pep63 is employed in research focused on Alzheimer's disease (AD). |
In vivo | Pep63 can be directly targeted to the dorsal hippocampus to effectively inhibit the interaction between EphB2 and ADDLs (Aβ-derived diffusible ligands), reversing memory impairments in early-stage AD mouse models. Transferrin-liposomes serve as a delivery vehicle, utilizing transferrin receptor (TfR)-mediated endocytosis to transport Pep63 into the brain. |
Molecular Weight | 1146.34 |
Formula | C51H87N17O13 |
Cas No. | 1781242-18-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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