PF 1022A is an N-methylated cyclooctadepsipeptides with strong anthelmintic properties. It also acts as an ionosphere.

PF1022A is a novel anthelmintic that binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. PF1022A binds to GABA receptors, which might contribute to the anthelmintic effect. Like other cyclodepsipeptides, PF1022A acts as an ionosphere. PF 1022A showed strong anthelmintic activities against Ascaridia galli in chickens. PF1022A showed low activity on embryonation but significantly inhibited egg hatch (10 and 100 μg/ml), whereas albendazole (10 and 100 μg/ml) revealed statistically significant inhibitions of both embryonation and egg hatch. PF1022A (1-100 μg/ml) fullly inhibited larval movement at most examination points [1][2][3].