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PF 1022A

Name: PF 1022A
Brand: TargetMol
SKU: T16497
Rating: 4.5 (1 reviews)

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Catalog No. T16497Cas No. 133413-70-4

PF 1022A is an N-methylated cyclooctadepsipeptides with strong anthelmintic properties. It also acts as an ionosphere.

PF 1022A

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Catalog No. T16497Cas No. 133413-70-4

PF 1022A is an N-methylated cyclooctadepsipeptides with strong anthelmintic properties. It also acts as an ionosphere.

Pack Size	Price	Availability	Quantity
1 mg	$296	35 days
5 mg	$1,200	35 days

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Product Introduction

Bioactivity

Description

PF 1022A is an N-methylated cyclooctadepsipeptides with strong anthelmintic properties. It also acts as an ionosphere.

In vitro

PF1022A is a novel anthelmintic that binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. PF1022A binds to GABA receptors, which might contribute to the anthelmintic effect. Like other cyclodepsipeptides, PF1022A acts as an ionosphere. PF 1022A showed strong anthelmintic activities against Ascaridia galli in chickens. PF1022A showed low activity on embryonation but significantly inhibited egg hatch (10 and 100 μg/ml), whereas albendazole (10 and 100 μg/ml) revealed statistically significant inhibitions of both embryonation and egg hatch. PF1022A (1-100 μg/ml) fullly inhibited larval movement at most examination points [1][2][3].

Chemical Properties

Molecular Weight	949.18
Formula	C₅₂H₇₆N₄O₁₂
Cas No.	133413-70-4
Relative Density.	1.15 (corresponds to D4(20)). Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 43 mg/mL (45.30 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0535 mL	5.2677 mL	10.5354 mL	52.6770 mL
5 mM	0.2107 mL	1.0535 mL	2.1071 mL	10.5354 mL
10 mM	0.1054 mL	0.5268 mL	1.0535 mL	5.2677 mL
20 mM	0.0527 mL	0.2634 mL	0.5268 mL	2.6339 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PF 1022A