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PF-06462894

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Catalog No. T28372Cas No. 1622291-66-0
Alias PF-6462894, PF6462894, PF 6462894

PF-06462894 is a morpholinopyrimidone mGlu5 (mGlu5 Ki = 6 nM) with favorable properties. PF-06462894 did not show any evidence of immune activation in a mouse drug allergy model.

PF-06462894

PF-06462894

😃Good
Catalog No. T28372Alias PF-6462894, PF6462894, PF 6462894Cas No. 1622291-66-0
PF-06462894 is a morpholinopyrimidone mGlu5 (mGlu5 Ki = 6 nM) with favorable properties. PF-06462894 did not show any evidence of immune activation in a mouse drug allergy model.
Pack SizePriceAvailabilityQuantity
25 mg$2,87010-14 weeks
50 mg$3,78010-14 weeks
100 mg$5,20010-14 weeks
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Product Introduction

Bioactivity
Description
PF-06462894 is a morpholinopyrimidone mGlu5 (mGlu5 Ki = 6 nM) with favorable properties. PF-06462894 did not show any evidence of immune activation in a mouse drug allergy model.
AliasPF-6462894, PF6462894, PF 6462894
Chemical Properties
Molecular Weight329.39
FormulaC18H23N3O3
Cas No.1622291-66-0
Relative Density.1.21 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PF 06462894PF-06462894PF06462894
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