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PF-07059013, an orally active and potent noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity and demonstrates substantial partitioning into red blood cells (RBCs), making it useful for sickle cell disease (SCD) research [1][2].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | 8-10 weeks | |
50 mg | Inquiry | 8-10 weeks |
Description | PF-07059013, an orally active and potent noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity and demonstrates substantial partitioning into red blood cells (RBCs), making it useful for sickle cell disease (SCD) research [1][2]. |
In vivo | PF-07059013 (10-490 mg/kg, oral gavage, twice daily for 2 weeks) demonstrated a reduction in sickling in Townes SCD mice [1]. |
Molecular Weight | 365.36 |
Formula | C19H16FN5O2 |
Cas No. | 2435610-93-6 |
Storage | Shipping with blue ice. |
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