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PF-07284892

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Catalog No. T79123Cas No. 2498597-94-5
Alias ARRY-558

PF-07284892 (ARRY-558) is an orally active, potent SHP2 inhibitor with an IC50 of 21 nM, known to reduce the expression of pERK [1] [2].

PF-07284892

PF-07284892

😃Good
Catalog No. T79123Alias ARRY-558Cas No. 2498597-94-5
PF-07284892 (ARRY-558) is an orally active, potent SHP2 inhibitor with an IC50 of 21 nM, known to reduce the expression of pERK [1] [2].
Pack SizePriceAvailabilityQuantity
25 mg$1,520 8-10 weeks
50 mg$1,980 8-10 weeks
100 mg$2,500 8-10 weeks
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Product Introduction

Bioactivity
Description
PF-07284892 (ARRY-558) is an orally active, potent SHP2 inhibitor with an IC50 of 21 nM, known to reduce the expression of pERK [1] [2].
In vitro
PF-07284892 (100 nM; 4, 18 h), in combination with lorlatinib (0-450 nM) or binimetinib (0-160 nM), reduces pERK expression in H3122 lorR-06 and VACO-432 cells [2].
In vivo
PF-07284892 (10 mg/kg; p.o.) exhibited high oral bioavailability, with F% values of 85% in mice, 94% in rats, 102% in dogs, and 64% in monkeys [2].
AliasARRY-558
Chemical Properties
Molecular Weight439.96
FormulaC21H22ClN7S
Cas No.2498597-94-5
Storage & Solubility Information
StorageShipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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