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PF-07284892

Name: PF-07284892
Brand: TargetMol
SKU: T79123
Rating: 4.5 (1 reviews)

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Catalog No. T79123Cas No. 2498597-94-5

Alias ARRY-558

PF-07284892 (ARRY-558) is an orally active, potent SHP2 inhibitor with an IC50 of 21 nM, known to reduce the expression of pERK [1] [2].

PF-07284892

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Catalog No. T79123Alias ARRY-558Cas No. 2498597-94-5

PF-07284892 (ARRY-558) is an orally active, potent SHP2 inhibitor with an IC50 of 21 nM, known to reduce the expression of pERK [1] [2].

Pack Size	Price	Availability
25 mg	$1,520	8-10 weeks
50 mg	$1,980	8-10 weeks
100 mg	$2,500	8-10 weeks

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Product Introduction

Bioactivity

Description	PF-07284892 (ARRY-558) is an orally active, potent SHP2 inhibitor with an IC50 of 21 nM, known to reduce the expression of pERK [1] [2].
In vitro	PF-07284892 (100 nM; 4, 18 h), in combination with lorlatinib (0-450 nM) or binimetinib (0-160 nM), reduces pERK expression in H3122 lorR-06 and VACO-432 cells [2].
In vivo	PF-07284892 (10 mg/kg; p.o.) exhibited high oral bioavailability, with F% values of 85% in mice, 94% in rats, 102% in dogs, and 64% in monkeys [2].
Alias	ARRY-558

Chemical Properties

Molecular Weight	439.96
Formula	C₂₁H₂₂ClN₇S
Cas No.	2498597-94-5

Storage & Solubility Information

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Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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