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PFI-7

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Catalog No. T88744Cas No. 2910938-58-6

PFI-7 is a probe that binds to human GID4 with a dissociation constant (KD) of 79 nM, antagonizing the binding of Pro/N-degron determinants peptides. It is useful in the study of the C-terminal to LisH (CTLH) complex and the development of targeted protein degradation.

PFI-7

PFI-7

😃Good
Catalog No. T88744Cas No. 2910938-58-6
PFI-7 is a probe that binds to human GID4 with a dissociation constant (KD) of 79 nM, antagonizing the binding of Pro/N-degron determinants peptides. It is useful in the study of the C-terminal to LisH (CTLH) complex and the development of targeted protein degradation.
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Product Introduction

Bioactivity
Description
PFI-7 is a probe that binds to human GID4 with a dissociation constant (KD) of 79 nM, antagonizing the binding of Pro/N-degron determinants peptides. It is useful in the study of the C-terminal to LisH (CTLH) complex and the development of targeted protein degradation.
Chemical Properties
Molecular Weight401.5
FormulaC24H27N5O
Cas No.2910938-58-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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