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PhAc-ALGP-Dox is a peptide-drug conjugate and a novel antitumor prodrug. It exhibits a range of IC50 values from 311 nM to 34.25 μM against TNBC (E0771), normal mouse epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human colorectal cancer (LS 174T), and normal human epithelium (HME-1) cells.
Pack Size | Price | Availability | Quantity |
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10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | PhAc-ALGP-Dox is a peptide-drug conjugate and a novel antitumor prodrug. It exhibits a range of IC50 values from 311 nM to 34.25 μM against TNBC (E0771), normal mouse epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human colorectal cancer (LS 174T), and normal human epithelium (HME-1) cells. |
In vitro | PhAc-ALGP-Dox is activated through a tumor-specific two-step cleavage process, initially triggered by extracellular THOP1, followed by further processing by FAPα/DPP4. |
Molecular Weight | 1003.94 |
Formula | C45H58N5O19P |
Cas No. | 1616592-31-4 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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