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Phenserine tartrate

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Catalog No. T89337Cas No. 156910-61-1
Alias (-)-Phenserine (+)-tartrate, (-)-Eseroline phenylcarbamate tartrate

Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and functions as an efficient, non-competitive, long-acting, and selective inhibitor of acetylcholinesterase (AChE). This compound reduces the formation of amyloid precursor protein (APP) and β-amyloid peptides (Aβ), potentially improving cognitive abilities and alleviating the progression of Alzheimers disease.

Phenserine tartrate
Other Forms of Phenserine tartrate:

Phenserine tartrate

😃Good
Catalog No. T89337Alias (-)-Phenserine (+)-tartrate, (-)-Eseroline phenylcarbamate tartrateCas No. 156910-61-1
Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and functions as an efficient, non-competitive, long-acting, and selective inhibitor of acetylcholinesterase (AChE). This compound reduces the formation of amyloid precursor protein (APP) and β-amyloid peptides (Aβ), potentially improving cognitive abilities and alleviating the progression of Alzheimers disease.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and functions as an efficient, non-competitive, long-acting, and selective inhibitor of acetylcholinesterase (AChE). This compound reduces the formation of amyloid precursor protein (APP) and β-amyloid peptides (Aβ), potentially improving cognitive abilities and alleviating the progression of Alzheimers disease.
In vitro
Phenserine, when administered at concentrations of 1-25 μM for 48 hours to CHO APP 751SW cells, demonstrates significant biological activity. Specifically, CHO APP 751SW cells treated with 10 μM of Phenserine exhibit an 18.6% reduction in cell viability, while a higher concentration of 25 μM results in a 51.4% decrease in APP levels.
In vivo
When administered intraperitoneally at doses of 1-4 mg/kg for a continuous period of four days, phenserine improves learning in spatial memory tasks where cholinergic function is impaired in male Fischer-344 rats.
Alias(-)-Phenserine (+)-tartrate, (-)-Eseroline phenylcarbamate tartrate
Chemical Properties
Molecular Weight487.5
FormulaC24H29N3O8
Cas No.156910-61-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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