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PhiKan 083 hydrochloride

Name: PhiKan 083 hydrochloride
Brand: TargetMol
SKU: T16523
Rating: 4.5 (1 reviews)

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Catalog No. T16523Cas No. 1050480-30-2

PhiKan 083 hydrochloride, a carbazole derivative, binds to the surface cavity and stabilizes Y220C (Kd: 167 μM) with a relative binding affinity (Kd) of 150 μM in Ln229 cells.

PhiKan 083 hydrochloride

😃Good

Catalog No. T16523Cas No. 1050480-30-2

PhiKan 083 hydrochloride, a carbazole derivative, binds to the surface cavity and stabilizes Y220C (Kd: 167 μM) with a relative binding affinity (Kd) of 150 μM in Ln229 cells.

Pack Size	Price	Availability	Quantity
10 mg	$618	35 days

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Product Introduction

Bioactivity

Description	PhiKan 083 hydrochloride, a carbazole derivative, binds to the surface cavity and stabilizes Y220C (Kd: 167 μM) with a relative binding affinity (Kd) of 150 μM in Ln229 cells.
Targets&IC50	p53-Y220C:（kd）167 μM
In vitro	PhiKan 083 slows down its thermal denaturation rate. PhiKan 083 shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells. PhiKan 083 (100 μM) in combination with NSC 123127 (1 μM) increases the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). PhiKan 083 (125 μM, 48 hours) decreases the cell viability of engineered variants of Ln229 cells [2][3].

Chemical Properties

Molecular Weight	274.79
Formula	C₁₆H₁₉ClN₂
Cas No.	1050480-30-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 2 mg/mL (7.28 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.6391 mL	18.1957 mL	36.3914 mL	181.9571 mL
5 mM	0.7278 mL	3.6391 mL	7.2783 mL	36.3914 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

PhiKan 083 hydrochloridePhiKan 083 Hydrochloridep53-Y220C