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Pibrozelesin

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Catalog No. T70462Cas No. 154889-68-6

Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.

Pibrozelesin

Pibrozelesin

😃Good
Catalog No. T70462Cas No. 154889-68-6
Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
Pack SizePriceAvailabilityQuantity
25 mg3.154 €10-14 weeks
50 mg4.161 €10-14 weeks
100 mg5.795 €10-14 weeks
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Product Introduction

Bioactivity
Description
Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
Chemical Properties
Molecular Weight698.56
FormulaC32H36BrN5O8
Cas No.154889-68-6
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PibrozelesinFCE27164FCE 27164
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