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Pip-alkyne-Ph-COOCH3

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Catalog No. T18545Cas No. 2308496-47-9

Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker used for synthesizing PROTAC ARD-266[1].

Pip-alkyne-Ph-COOCH3

Pip-alkyne-Ph-COOCH3

😃Good
Catalog No. T18545Cas No. 2308496-47-9
Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker used for synthesizing PROTAC ARD-266[1].
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Product Introduction

Bioactivity
Description
Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker used for synthesizing PROTAC ARD-266[1].
In vitro
ARD-266 is a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader[1].
Chemical Properties
Molecular Weight243.3
FormulaC15H17NO2
Cas No.2308496-47-9
Relative Density.1.13 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Pip alkyne Ph COOCH3PipalkynePhCOOCH3Pip-alkyne-Ph-COOCH3Pip-alkyne-Ph-COOCH-3
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