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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | Inquiry | 1-2 weeks | |
50 mg | Inquiry | 1-2 weeks | |
100 mg | Inquiry | 1-2 weeks |
Description | Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an improved efficacy and safety compared with tamoxifen. In the combination with temsirolimus, ERA-923 showed excellent anticancer activity in preclinical models. |
Molecular Weight | 456.58 |
Formula | C29H32N2O3 |
Cas No. | 198480-55-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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