Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].

Pomalidomide-amido-C1-Br (Compound 6) serves as a precursor for synthesizing PROTAC B-Raf degrader 1 (Compound 2), an effective anticancer agent that induces apoptosis in cancer cells by accelerating B-Raf degradation via the ubiquitin-proteasome system, affecting Mcl-1 expression, a downstream protein associated with B-Raf, highlighting its mechanism of action[1].