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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $169 | 5 days |
Description | Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1]. |
In vitro | Pomalidomide-amido-C1-Br (Compound 6) serves as a precursor for the synthesis of PROTAC B-Raf degrader 1 (Compound 2), an effective anticancer agent. It operates by inducing apoptosis in cancer cells primarily through the accelerated degradation of B-Raf, leveraging the ubiquitin-proteasome system. Furthermore, this degradation pathway impacts the expression of Mcl-1, a downstream protein associated with B-Raf, highlighting its mechanism of action[1]. |
Molecular Weight | 394.18 |
Formula | C15H12BrN3O5 |
Cas No. | 2351106-38-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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