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Pomalidomide-6-OH

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Catalog No. T77927Cas No. 1547162-44-6

Pomalidomide-6-OH, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC [1]).

Pomalidomide-6-OH

Pomalidomide-6-OH

😃Good
Catalog No. T77927Cas No. 1547162-44-6
Pomalidomide-6-OH, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC [1]).
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Product Introduction

Bioactivity
Description
Pomalidomide-6-OH, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC [1]).
In vitro
PROTACs consist of two ligands linked together: one for E3 ubiquitin ligase and the other for the target protein. By harnessing the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins [1].
Chemical Properties
Molecular Weight289.24
FormulaC13H11N3O5
Cas No.1547162-44-6
Storage & Solubility Information
StorageShipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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