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PPACK Dihydrochloride (71142-71-7 free base)

Catalog No. T23177

PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective, and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant (Ki: 0.24 nM).

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Pack Size	Price	Availability	Quantity
5 mg	$468	Backorder

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Product Introduction

Bioactivity

Description	PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective, and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant (
In vitro	PPACK covalently binds to the specific active-site Ser of thrombin and cross-links with His57 at the binding site forming a tetrahedral PPACK-thrombin complex. The complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. PPACK is currently being investigated as an anti-coagulant to prevent blood coagulation. Study results show that PPACK is able to dose-dependently inhibit thrombin-induced platelet accumulation.
Alias	PPACK Dihydrochloride

Chemical Properties

Molecular Weight	523.88
Formula	C21H31ClN6O3·2HCl
Cas No.

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	HCL: Soluble

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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