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Pravastatin lactone

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Catalog No. T37642Cas No. 85956-22-5

Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.

Pravastatin lactone

Pravastatin lactone

😃Good
Catalog No. T37642Cas No. 85956-22-5
Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.
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5 mg$273 7-10 days
10 mg$396 7-10 days
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Product Introduction

Bioactivity
Description
Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.
Chemical Properties
Molecular Weight406.519
FormulaC23H34O6
Cas No.85956-22-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (49.2 mM), Sonication is recommended.
DMF: 25 mg/mL (61.5 mM), Sonication is recommended.
PBS (pH 7.2): 10 mg/mL (24.6 mM), Sonication is recommended.
Ethanol: 12.5 mg/mL (30.75 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM2.4599 mL12.2995 mL24.5991 mL122.9955 mL
5 mM0.4920 mL2.4599 mL4.9198 mL24.5991 mL
10 mM0.2460 mL1.2300 mL2.4599 mL12.2995 mL
20 mM0.1230 mL0.6150 mL1.2300 mL6.1498 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pravastatin lactone
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