PRO-6E is an orally active, Cereblon ligand-based PROTAC that promotes MET degradation, achieving up to 81.9% effectiveness at a concentration of 1 μM in MKN-45 cells. It demonstrates tumor growth inhibition both in vivo and in vitro, alongside inducing cell apoptosis and cell cycle arrest. Notably, its structure comprises a Cereblon ligand (blue), a linker (black), and an ALK/c-Met inhibitor Crizotinib component (pink). [1]