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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Procyclidine (Tricyclamol; (±)-Procyclidine) is an anticholinergic agent which is a muscarinic receptor antagonist as well as an N-methyl-D-aspartate ( NMDA ) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders, for example, Soman-induced epilepsy [1] [2]. |
In vivo | Procyclidine, when administered subcutaneously at dosages between 0.3-6.0 mg/kg in conjunction with physostigmine (PhS), exhibits increased dose-dependent protective effects against soman in rats and guinea pigs, significantly reducing or entirely preventing seizures. The study utilized male Sprague-Dawley rats and Dunkin-Hartley male guinea pigs, observing a substantial enhancement in protection. Specifically, protection levels in rats enhanced by 1.92, 2.24, 3.95, and 5.07 times, and in guinea pigs by 3.00, 3.25, 4.50, and 4.70 times at dosages of 0.3, 1.0, 3.0, and 6.0 mg/kg, respectively. This combination treatment safeguarded neurological brain integrity, effectively preventing severe damage in critical brain areas such as the hippocampus, cortex, amygdala, and thalamus induced by soman exposure. |
Molecular Weight | 287.44 |
Formula | C19H29NO |
Cas No. | 77-37-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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