Prolactin Releasing Peptide (1-31), human (acetate), is a potent GPR10 ligand with high affinity, eliciting prolactin secretion. It binds to human and rat GPR10 with K_i values of 1.03 nM and 0.33 nM, respectively, and serves as a tool for researching the hypothalamo-pituitary axis [1] [2].

Prolactin Releasing Peptide (1-31), human (acetate), shows high affinity for the GPR10 receptor in humans and rats, with Ki values of 1.03 nM and 0.33 nM, respectively [1].

Prolactin Releasing Peptide (1-31), human (acetate), administered intracerebroventricularly (ICV) at 5 nM, enhances plasma follicle-stimulating hormone (FSH), elevates total plasma testosterone levels, and significantly augments luteinizing hormone-releasing hormone (LHRH) release from in vitro hypothalamic explants [2]. At 100 nM ICV, it upregulates hypothalamic peptides regulating pituitary hormone secretion, specifically vasoactive intestinal peptide (VIP) and galanin, without affecting orexin A secretion [2].