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Pronetalol

Name: Pronetalol
Brand: TargetMol
SKU: T1271
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T1271Cas No. 54-80-8

Pronethalol ((±)-Pronethalol), a non-selective β-adrenergic antagonist, effectively inhibits Sox2 expression and offers protection against Digitalis-induced ventricular arrhythmias. Additionally, it can reverse such arrhythmias and limit the development of cerebral arteriovenous malformations (AVMs) [1] [2].

Pronetalol

Catalog No. T1271Cas No. 54-80-8

Pack Size	Price	Availability	Quantity
5 mg	$41	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Product Introduction

Bioactivity

Description	Pronethalol ((±)-Pronethalol), a non-selective β-adrenergic antagonist, effectively inhibits Sox2 expression and offers protection against Digitalis-induced ventricular arrhythmias. Additionally, it can reverse such arrhythmias and limit the development of cerebral arteriovenous malformations (AVMs) [1] [2].
In vitro	Pronethalol (2, 10, 20 μM) inhibits EGFP expression in a dose- and time-dependent manner in ReNcell VM cells, with 10 μM reducing Sox2 expression to less than 10% after 2 days of treatment [2].
In vivo	Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation and lumen formation, thereby limiting cerebral arteriovenous malformations (AVMs) in Mgp –/– mice [2].

Chemical Properties

Molecular Weight	229.32
Formula	C₁₅H₁₉NO
Cas No.	54-80-8

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 10 mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3607 mL	21.8036 mL	43.6072 mL	218.0359 mL
5 mM	0.8721 mL	4.3607 mL	8.7214 mL	43.6072 mL
10 mM	0.4361 mL	2.1804 mL	4.3607 mL	21.8036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pronetalol