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Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

Name: Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite
Brand: TargetMol
SKU: T39151
Price: 71 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T39151Cas No. 1682657-14-2

Alias Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule designed for synthesizing proteolysis-targeting chimeras (PROTACs).

Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

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Catalog No. T39151Alias Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramiditeCas No. 1682657-14-2

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule designed for synthesizing proteolysis-targeting chimeras (PROTACs).

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Product Introduction

Bioactivity

Description	Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule designed for synthesizing proteolysis-targeting chimeras (PROTACs).
In vitro	PROTACs comprise two distinct ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, while the other targets the protein of interest. They leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins[1].
Alias	Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

Chemical Properties

Molecular Weight	432.498
Formula	C₂₀H₃₇N₂O₆P
Cas No.	1682657-14-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Propargyl-PEG-5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramiditePropargyl PEG5 1 o (b cyanoethyl n,n diisopropyl)phosphoramiditePropargylPEG51o(bcyanoethyln,ndiisopropyl)phosphoramidite

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