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Prostaglandin E3

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Catalog No. T38194Cas No. 802-31-3
Alias PGE3

Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells.

Prostaglandin E3
Other Forms of Prostaglandin E3:
17-trans Prostaglandin E3T85388210979-33-2
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Prostaglandin E3

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Purity: 98%
Catalog No. T38194Alias PGE3Cas No. 802-31-3
Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells.
Pack SizePriceAvailabilityQuantity
100 μg$1,100In Stock
500 μg$3,21035 days
1 mg$4,88035 days
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Concentration:0.2 mg/mL
Purity:98%
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Product Introduction

Bioactivity
Description
Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells.
In vitro
METHODS: To investigate the role of Prostaglandin E3 in modulating macrophage polarization, THP-1 cells (a human monocytic cell line) were used to induce macrophage polarization, and the effects of different concentrations of Prostaglandin E3 on the markers of M1 and M2 macrophages were observed.
RESULTS: Prostaglandin E3 (1-10000 nM) was found to inhibit the expression of M1 macrophage markers while promoting the polarization towards M2 macrophages[1].
In vivo
METHODS: To investigate the effect of Prostaglandin E3 on the proliferation of prostate tumor cells, prostate tumor cells were injected into mice, and Prostaglandin E3 was continuously administered during the experiment to observe the growth of the tumors and the infiltration of macrophages.
RESULTS: Continuous injection of Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) significantly reduced the weight of the transplanted tumors and decreased the expression of CD68 and CD206 (markers of M2 macrophages) within the tumors[1].
AliasPGE3
Chemical Properties
Molecular Weight350.45
FormulaC20H30O5
Cas No.802-31-3
SmilesC(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](C/C=C\CC)O)[C@H](O)CC1=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (85.60 mM), Sonication is recommended.
DMF: 30 mg/mL (85.60 mM), Sonication is recommended.
Ethanol: 30 mg/mL (85.60 mM);, Sonication is recommended.
Solution Preparation Table
DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.8535 mL14.2674 mL28.5347 mL142.6737 mL
5 mM0.5707 mL2.8535 mL5.7069 mL28.5347 mL
10 mM0.2853 mL1.4267 mL2.8535 mL14.2674 mL
20 mM0.1427 mL0.7134 mL1.4267 mL7.1337 mL
50 mM0.0571 mL0.2853 mL0.5707 mL2.8535 mL

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Keywords

PGE-3Prostaglandin E3PGE 3Prostaglandin E-3
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