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PROTAC BRD4 Degrader-15

Name: PROTAC BRD4 Degrader-15
Brand: TargetMol
SKU: T40074
Rating: 4.5 (1 reviews)

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Catalog No. T40074Cas No. 2417370-67-1

Alias PROTAC BRD4 Degrader-15

PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2 and demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.

PROTAC BRD4 Degrader-15

😃Good

Catalog No. T40074Alias PROTAC BRD4 Degrader-15Cas No. 2417370-67-1

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Product Introduction

Bioactivity

Description	PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2 and demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
Targets&IC50	BRD4 BD2:8.1 nM (IC50), BRD4 BD1:7.2 nM (IC50)
In vitro	PROTAC BRD4 Degrader-15 (compound 13) effectively reduces MYC gene expression in MV4-11 AML cells within 4 hours with an IC50 of 15 nM[1], and over 6 days, significantly inhibits the growth of HL-60 and PC3-S1 cells with IC50 values of 4.2 nM and 91 nM, respectively[1].
Alias	PROTAC BRD4 Degrader-15

Chemical Properties

Molecular Weight	1149.3
Formula	C₅₇H₆₂F₂N₁₀O₁₀S₂
Cas No.	2417370-67-1
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

PROTAC BRD4 Degrader15PROTAC BRD-4 Degrader-15PROTAC BRD4 Degrader 15