Protizinic acid inhibits phospholipase A2 (PLA2) with an IC 50 of 210 μM. Protizinic acid has antiinflammatory and antipyretic activity which is an orally active non-steroidal antiinflammatory agent [1] [2].

Protizinic acid both inhibits the in vitro production of leukokinin and acts antagonistically towards it at its receptor site [1].

Utilizing an in vivo leukokinin (LK) generation system in a feline acute ischemia model, the administration of 3 mg/kg Protizinic acid via intravenous injection twice to cats experiencing acute cardiac ischemia inhibits increased blood acid protease activity and significantly prevents the reduction of leukokininogen, leukokinin's precursor [1]. Furthermore, the oral intake of 30 mg/kg Protizinic acid markedly reduces arachidonic acid-induced erythema in guinea pigs [2].