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Protriptyline
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Catalog No. T60430Cas No. 438-60-8
Protriptyline is a potent antidepressant agent that inhibits AChE activity with an IC 50 value of 0.06 mM as well as inhibits Aβ Self-Assembly. Protriptyline has the potential to be used for depression and Alzheimer's disease [1] [2] [3].
Protriptyline
😃Good
Catalog No. T60430Cas No. 438-60-8
Protriptyline is a potent antidepressant agent that inhibits AChE activity with an IC 50 value of 0.06 mM as well as inhibits Aβ Self-Assembly. Protriptyline has the potential to be used for depression and Alzheimer's disease [1] [2] [3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Protriptyline is a potent antidepressant agent that inhibits AChE activity with an IC 50 value of 0.06 mM as well as inhibits Aβ Self-Assembly. Protriptyline has the potential to be used for depression and Alzheimer's disease [1] [2] [3]. |
| In vitro | Protriptyline (0-70 μM; 24 hours; PC3 cells) induces cytotoxicity in PC3 cells, decreasing cell viability in a concentration-dependent manner (50, 60, and 70 μM) [2]. |
| In vivo | Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) ameliorates spatial learning and retention memory in STZ-treated rats [3]. The treatment significantly reduced pTau, Aβ42, and BACE-1 levels, neurodegeneration, oxidative stress, and glial activation, while improving the p-ERK/ERK ratio, and enhancing BDNF and CREB levels by reducing NFκB and GFAP expression. |
| Molecular Weight | 263.38 |
| Formula | C19H21N |
| Cas No. | 438-60-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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