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PSI-697

Name: PSI-697
Brand: TargetMol
SKU: T16676
Price: 126 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16676Cas No. 851546-61-7

Alias P-Selectin Inhibitor

PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM).

PSI-697

😃Good

Catalog No. T16676Alias P-Selectin InhibitorCas No. 851546-61-7

PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM).

Pack Size	Price	Availability
25 mg	1.729 €	1-2 weeks
50 mg	2.261 €	1-2 weeks
100 mg	2.945 €	1-2 weeks
1 mL x 10 mM (in DMSO)	264 €	1-2 weeks

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Product Introduction

Bioactivity

Description	PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM).
Targets&IC50	P-selectin:125 μM
In vitro	PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1. In vitro, as a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM [1].
In vivo	PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and reduces inflammation in a baboon model of venous thrombosis. PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis. PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to the vehicle, without prolonging bleeding time in a rat venous thrombosis model. PSI-697 (0-50 mg/kg; p.o.) obviously decreases the number of rolling leukocytes by 39% versus vehicle control[1][2].
Alias	P-Selectin Inhibitor

Chemical Properties

Molecular Weight	367.83
Formula	C₂₁H₁₈ClNO₃
Cas No.	851546-61-7
Relative Density.	1.383 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45.8 mg/mL (124.51 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7186 mL	13.5932 mL	27.1865 mL	135.9324 mL
5 mM	0.5437 mL	2.7186 mL	5.4373 mL	27.1865 mL
10 mM	0.2719 mL	1.3593 mL	2.7186 mL	13.5932 mL
20 mM	0.1359 mL	0.6797 mL	1.3593 mL	6.7966 mL
50 mM	0.0544 mL	0.2719 mL	0.5437 mL	2.7186 mL
100 mM	0.0272 mL	0.1359 mL	0.2719 mL	1.3593 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PSI-697PSI697PSI 697P-selectin