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Pt(IV)-M13 is a platinum (IV) prodrug conjugated with a perfluoroaryl macrocyclic peptide, capable of crossing the blood-brain barrier. It exhibits cytotoxicity towards glioblastoma stem cells and enhances platinum uptake in the brain, making it a valuable tool for glioblastoma research.
Pack Size | Price | Availability | Quantity |
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10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Pt(IV)-M13 is a platinum (IV) prodrug conjugated with a perfluoroaryl macrocyclic peptide, capable of crossing the blood-brain barrier. It exhibits cytotoxicity towards glioblastoma stem cells and enhances platinum uptake in the brain, making it a valuable tool for glioblastoma research. |
In vitro | Pt(IV)-M13, at concentrations ranging from 1-30 μM over a duration of 80 hours, exhibits an IC50 of approximately 5 μM against G9 neurospheres, similar to cisplatin. |
In vivo | Administering a single dose of Pt(IV)-M13 (2.5 mg/kg;I.V.) to mice can significantly enhance platinum accumulation in the brain, achieving levels 15 times higher than those observed with cisplatin. |
Molecular Weight | 2947.63 |
Formula | C120H190ClF8N30O28PtS2 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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