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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,530 | 8-10 weeks | |
50 mg | $1,990 | 8-10 weeks | |
100 mg | $3,100 | 8-10 weeks |
Description | PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1]. PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment[1].PW0464 (compound 24), the non-catechol agonist, forms bonds with S1985.42 and S2025.46 via its fluorine atom[2]. [1]. Pingyuan Wang, et al. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med Chem Lett[2]. David R Sibley, et al. Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential. Signal Transduct Target Ther. 2021 May 22;6(1):205. |
In vitro | PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment[1].PW0464 (compound 24), the non-catechol agonist, forms bonds with S1985.42 and S2025.46 via its fluorine atom[2]. |
Alias | PW0464 |
Molecular Weight | 389.35 |
Formula | C19H17F2N3O4 |
Cas No. | 1643462-93-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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