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PW0464

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Catalog No. T36946Cas No. 1643462-93-4
Alias PW0464

PW0464, a nanomolar potent complete G protein-biased ligand, is a noncatechol D1R agonist with an EC50 of 5.8 nM (Gs-cAMP)[1].

PW0464

PW0464

😃Good
Catalog No. T36946Alias PW0464Cas No. 1643462-93-4
PW0464, a nanomolar potent complete G protein-biased ligand, is a noncatechol D1R agonist with an EC50 of 5.8 nM (Gs-cAMP)[1].
Pack SizePriceAvailabilityQuantity
25 mg$1,5308-10 weeks
50 mg$1,9908-10 weeks
100 mg$3,1008-10 weeks
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Product Introduction

Bioactivity
Description
PW0464, a nanomolar potent complete G protein-biased ligand, is a noncatechol D1R agonist with an EC50 of 5.8 nM (Gs-cAMP)[1].
In vitro
PW0464 (compound 24) exhibits full G protein bias with no D1R-mediated β-arrestin recruitment activity[1]. As a non-catechol agonist, it forms bonds with S1985.42 and S2025.46 through its fluorine atom[2].
AliasPW0464
Chemical Properties
Molecular Weight389.35
FormulaC19H17F2N3O4
Cas No.1643462-93-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PW-0464PW 0464
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