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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | $155 | 35 days | |
1 mg | $288 | 35 days | |
5 mg | $1,190 | 35 days | |
10 mg | $1,980 | 35 days |
Description | Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification. |
Molecular Weight | 358.91 |
Formula | C20H27ClN4 |
Cas No. | 1411646-44-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: 10 mg/mL DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL Ethanol: 5 mg/mL DMF: 10 mg/mL |
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