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Rapacuronium bromide

Catalog No. T12690Cas No. 156137-99-4

Rapacuronium bromide is an allosteric muscarinic acetylcholine receptor (mAChR) modulator.

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Pack Size	Price	Availability
5 mg	$347	6-8 weeks
25 mg	$987	6-8 weeks
50 mg	$1,320	6-8 weeks
100 mg	$2,150	6-8 weeks

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Questions

Product Introduction

Bioactivity

Description	Rapacuronium bromide is an allosteric muscarinic acetylcholine receptor (mAChR) modulator.
In vitro	Rapacuronium accelerates the rate of ACh binding but decreases its affinity under equilibrium conditions.?This results in potentiation of receptor activation at low concentrations of rapacuronium (1 microM) but not at high concentrations (10 microM).?These observations highlight the relevance and necessity of performing physiological tests under non-equilibrium conditions in evaluating the functional effects of allosteric modulators at muscarinic receptors.
In vivo	Time course of the neuromuscular effects of Rapacuronium following the administration of the 2×ED90 doses to rats and guinea-pigs(ED90 of 5953±199 and 187±16 μg/kg in rat and guinea pig, respectively)[2].
Alias	Org 9487

Chemical Properties

Molecular Weight	677.8
Formula	C37H61BrN2O4
Cas No.	156137-99-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (184.42 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4754 mL	7.3768 mL	14.7536 mL	73.7681 mL
5 mM	0.2951 mL	1.4754 mL	2.9507 mL	14.7536 mL
10 mM	0.1475 mL	0.7377 mL	1.4754 mL	7.3768 mL
20 mM	0.0738 mL	0.3688 mL	0.7377 mL	3.6884 mL
50 mM	0.0295 mL	0.1475 mL	0.2951 mL	1.4754 mL
100 mM	0.0148 mL	0.0738 mL	0.1475 mL	0.7377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc