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RAS/RAS-RAF-IN-1

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Catalog No. T36642Cas No. 2447039-81-6

RAS/RAS-RAF-IN-1 is a potent inhibitor of RAS and RAS-RAF, exhibiting a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity and demonstrating antitumor activity[1].

RAS/RAS-RAF-IN-1

RAS/RAS-RAF-IN-1

😃Good
Catalog No. T36642Cas No. 2447039-81-6
RAS/RAS-RAF-IN-1 is a potent inhibitor of RAS and RAS-RAF, exhibiting a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity and demonstrating antitumor activity[1].
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Product Introduction

Bioactivity
Description
RAS/RAS-RAF-IN-1 is a potent inhibitor of RAS and RAS-RAF, exhibiting a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity and demonstrating antitumor activity[1].
In vitro
RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) exhibits an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1].
Chemical Properties
Molecular Weight807.993
FormulaC45H57N7O7
Cas No.2447039-81-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

RAS/RAS RAF IN 1RAS/RASRAFIN1RAS/RAS-RAF-IN-1
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