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Refanezumab
Catalog No. T77388Cas No. 1233953-61-1
Alias GSK249320, GSK 249320
Refanezumab (GSK249320) is an IgG1 humanized monoclonal antibody that crosses the blood-brain barrier (BBB) and targets myelin-associated glycoprotein (MAG) for the study of neurological and cardiovascular diseases.
Refanezumab
Refanezumab
Catalog No. T77388Alias GSK249320, GSK 249320Cas No. 1233953-61-1
Refanezumab (GSK249320) is an IgG1 humanized monoclonal antibody that crosses the blood-brain barrier (BBB) and targets myelin-associated glycoprotein (MAG) for the study of neurological and cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $450 | In Stock | |
| 5 mg | $1,400 | In Stock | |
| 10 mg | $2,220 | In Stock | |
| 25 mg | $4,210 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Refanezumab (GSK249320) is an IgG1 humanized monoclonal antibody that crosses the blood-brain barrier (BBB) and targets myelin-associated glycoprotein (MAG) for the study of neurological and cardiovascular diseases. |
| In vivo | Male Sprague Dawley rats were administered 10 mg/kg Refanezumab intravenously starting 24 hours after stroke onset and repeated weekly for a total of 6 doses. The results showed that this treatment resulted in significant improvements in neurologic scores and step tests. Refanezumab was able to penetrate the damaged area and had some positive impact on functional recovery within 24 hours of stroke. [1] |
| Alias | GSK249320, GSK 249320 |
| Molecular Weight | 145.5 kDa |
| Cas No. | 1233953-61-1 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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