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Retaspimycin Hydrochloride

Name: Retaspimycin Hydrochloride
Brand: TargetMol
SKU: T12726L
Rating: 4.5 (1 reviews)

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Catalog No. T12726LCas No. 857402-63-2

Alias IPI-504

Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).

Retaspimycin Hydrochloride

😃Good

Catalog No. T12726LAlias IPI-504Cas No. 857402-63-2

Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).

Pack Size	Price	Availability
2 mg	$107	5 days
5 mg	$177	5 days
10 mg	$327	5 days
50 mg	$747	6-8 weeks
100 mg	$1,250	6-8 weeks
1 mL x 10 mM (in DMSO)	$264	5 days

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Product Introduction

Bioactivity

Description	Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).
Targets&IC50	HSP90:119 nM （EC50）, Grp94:119 nM （EC50）
In vitro	Retaspimycin is an inhibitor of Hsp90. Retaspimycin can abrogate both the unfolded protein response element (UPRE) and ERSE-driven luciferase activity in non-treated U266 and MM.1s cells as well as in Tunicamycin (Tm)-treated cells. Incubation of Retaspimycin potently suppresses both Akt and MAPKs phosphorylation in both sensitive and Trastuzumab-resistant cells. Total levels of Akt decreased in all 4 cell lines (BT474, SKBR-3, HCC1569, and HCC1569) in a dose-dependent manner. However, levels of total MAPKs are not significantly altered with Retaspimycin treatment[2].
In vivo	Tumor regression of Trastuzumab-sensitive BT474 cell-derived xenografts independently induceed by Retaspimycin and Trastuzumab. Xenografts derived from BT474R cells continue to grow in the presence of Trastuzumab but are still sensitive to Retaspimycin. When used in combination, Retaspimycin and Trastuzumab add only marginal benefits to Retaspimycin monotherapy. Retaspimycin as a single agent is more efficacious than Trastuzumab in inhibiting tumor growth in HCC1569 xenografts[2].
Alias	IPI-504

Chemical Properties

Molecular Weight	624.17
Formula	C₃₁H₄₆ClN₃O₈
Cas No.	857402-63-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 56 mg/mL (89.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6021 mL	8.0106 mL	16.0213 mL	80.1064 mL
5 mM	0.3204 mL	1.6021 mL	3.2043 mL	16.0213 mL
10 mM	0.1602 mL	0.8011 mL	1.6021 mL	8.0106 mL
20 mM	0.0801 mL	0.4005 mL	0.8011 mL	4.0053 mL
50 mM	0.0320 mL	0.1602 mL	0.3204 mL	1.6021 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Retaspimycin HydrochlorideIPI504IPI 504HSP90GRP94