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RhlR antagonist 1

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Catalog No. T60249

RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modulate quorum sensing and control P. aeruginosa infections [1].

RhlR antagonist 1

RhlR antagonist 1

😃Good
Catalog No. T60249
RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modulate quorum sensing and control P. aeruginosa infections [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,52010-14 weeks
50 mg$1,98010-14 weeks
100 mg$2,50010-14 weeks
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Product Introduction

Bioactivity
Description
RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modulate quorum sensing and control P. aeruginosa infections [1].
In vitro
RhlR antagonist 1 (compound 30) at 10 μM significantly impedes P. aeruginosa biofilm formation by 74%, concurrently reducing carbohydrate and protein content by 39% and 72%, respectively, and markedly curtails rhamnolipid synthesis at both 10 and 100 μM. A 24-hour exposure to 0-10 μM levels notably suppresses rhlA gene expression in biofilm cells. Thus, this compound effectively obstructs P. aeruginosa biofilms and virulence factor production by down-regulating rhlA expression in P. aeruginosa.
In vivo
Larvae administered with P. aeruginosa began experiencing mortality within the initial incubation phase, resulting in a 70% mortality rate by the conclusion of the 20-day period. Treatment with RhlR antagonist 1 (0-10 μM) significantly enhanced survival, with about 80% of larvae surviving by the period's end. Moreover, larvae inoculated with rhlR mutants of P. aeruginosa exhibited a 90% survival rate after 20 days [1].
Chemical Properties
Molecular Weight208.2
FormulaC12H10F2O
Storage & Solubility Information
StorageShipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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