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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,350 | Backorder | |
50 mg | $1,760 | Backorder | |
100 mg | $2,680 | Backorder |
Description | RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC 50 of 11.1 μM which also inhibits homologous recombination(HR) activity in human cells with IC50 of 3.0 μM[1]. |
In vitro | RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA) [1]. When challenged with high salt concentrations, RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes[1]. |
Alias | RI(dl)-2 |
Molecular Weight | 287.36 |
Formula | C19H17N3 |
Cas No. | 1902146-75-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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