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RO-28-1675
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Catalog No. T16793Cas No. 300353-13-3
Alias Ro 28-1675
Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM).
RO-28-1675
😃Good
Catalog No. T16793Alias Ro 28-1675Cas No. 300353-13-3
Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $726 | 6-8 weeks | |
| 50 mg | $943 | 6-8 weeks | |
| 100 mg | $1,420 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM). |
| Targets&IC50 | GK:54 nM (EC50) |
| In vitro | Ro 28-1675 (50 mg/Kg; p.o.;) treatment to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle-treated animals. Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with an SC1.5 of 0.24 uM, while the S isomer did not activate GK up to 10 uM. A comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT following a single oral dose, was well tolerated and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg) [1] |
| Alias | Ro 28-1675 |
| Molecular Weight | 378.51 |
| Formula | C18H22N2O3S2 |
| Cas No. | 300353-13-3 |
| Relative Density. | 1.306 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (132.10 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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