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RO-28-1675

Name: RO-28-1675
Brand: TargetMol
SKU: T16793
Price: 36 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T16793Cas No. 300353-13-3

Alias Ro 28-1675

Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM).

RO-28-1675

Catalog No. T16793Alias Ro 28-1675Cas No. 300353-13-3

Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM).

Pack Size	Price	Availability
25 mg	$726	6-8 weeks
50 mg	$943	6-8 weeks
100 mg	$1,420	6-8 weeks

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Product Introduction

Bioactivity

Description	Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM).
Targets&IC50	GK:54 nM (EC50)
In vitro	Ro 28-1675 (50 mg/Kg; p.o.;) treatment to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle-treated animals. Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with an SC1.5 of 0.24 uM, while the S isomer did not activate GK up to 10 uM. A comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT following a single oral dose, was well tolerated and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg) [1]
Alias	Ro 28-1675

Chemical Properties

Molecular Weight	378.51
Formula	C₁₈H₂₂N₂O₃S₂
Cas No.	300353-13-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (132.10 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6419 mL	13.2097 mL	26.4194 mL	132.0969 mL
5 mM	0.5284 mL	2.6419 mL	5.2839 mL	26.4194 mL
10 mM	0.2642 mL	1.3210 mL	2.6419 mL	13.2097 mL
20 mM	0.1321 mL	0.6605 mL	1.3210 mL	6.6048 mL
50 mM	0.0528 mL	0.2642 mL	0.5284 mL	2.6419 mL
100 mM	0.0264 mL	0.1321 mL	0.2642 mL	1.3210 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RO281675RO-28-1675RO 28 1675