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Ro15-4513
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Catalog No. T16775Cas No. 91917-65-6
Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.
Ro15-4513
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Catalog No. T16775Cas No. 91917-65-6
Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $143 | 5 days | |
| 25 mg | $882 | 6-8 weeks | |
| 50 mg | $1,170 | 6-8 weeks | |
| 100 mg | $1,770 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist. |
| In vitro | Ro15-4513 typically functions as a partial inverse agonist at GABAA receptors [3]. |
| In vivo | Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice. Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) fully inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing [2]. |
| Molecular Weight | 326.31 |
| Formula | C15H14N6O3 |
| Cas No. | 91917-65-6 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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