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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,420 | 10-14 weeks | |
50 mg | $3,180 | 10-14 weeks | |
100 mg | $4,300 | 10-14 weeks |
Description | Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively). |
Targets&IC50 | 5-HT:, TPH1:33 nM, TPH2:7 nM |
In vivo | Rodatristat (10-50 mg/kg; p.o.; mice) treatment reduces intestinal 5-HT concentrations significantly at 50 mg/kg, with efficacy markedly diminishing at 10 mg/kg [1]. |
Alias | KAR5417 |
Molecular Weight | 561.98 |
Formula | C27H27ClF3N5O3 |
Cas No. | 1673568-73-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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