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RP-001 hydrochloride

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Catalog No. T12780LCas No. 1781880-34-9

RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

RP-001 hydrochloride
Other Forms of RP-001 hydrochloride:
RP-001T127801306761-53-4
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RP-001 hydrochloride

😃Good
Catalog No. T12780LCas No. 1781880-34-9
RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5.
Pack SizePriceAvailabilityQuantity
1 mg$9335 days
5 mg$39435 days
10 mg$62335 days
25 mg$1,32035 days
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Product Introduction

Bioactivity
Description
RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5.
In vitro
Dose-dependent lymphopenia of CD4+ T cells elicited by RP-001 hydrochloride. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels.
In vivo
Dose-dependent rapid lymphopenia caused by RP-001 hydrochloride(EC50 of 0.03 mg/kg).
Chemical Properties
Molecular Weight468.93
FormulaC24H25ClN4O4
Cas No.1781880-34-9
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

RP001 hydrochlorideRP 001 hydrochlorideRP 001 HydrochlorideRP-001 HydrochlorideRP001 Hydrochloride
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