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RT-AM

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Catalog No. T12776

RT-AM is a pro-drug real thiol. Real Thiol is a reversible reaction-based fluorescent probe.

RT-AM

RT-AM

😃Good
Catalog No. T12776
RT-AM is a pro-drug real thiol. Real Thiol is a reversible reaction-based fluorescent probe.
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1 mg272 €Backorder
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Product Introduction

Bioactivity
Description
RT-AM is a pro-drug real thiol. Real Thiol is a reversible reaction-based fluorescent probe.
In vitro
The carboxylic acid groups is converted to acetoxymethyl (AM) esters to enhance the cell permeability of Real Thiol, which are hydrolysed by esterases to regenerate Real Thiol inside cells. For cells treated with the RT-AM, real-time ratiometric images of rapid changes in intracellular GSH concentrations can be generated by dividing fluorescence intensity values of the 405 nm channel by the 488 nm channel at each corresponding pixel.
Chemical Properties
Molecular Weight555.49
FormulaC26H25N3O11
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RT AMRT-AMRTAM
Related Tags: buy RT-AM | purchase RT-AM | RT-AM cost | order RT-AM | RT-AM chemical structure | RT-AM in vitro | RT-AM formula | RT-AM molecular weight
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