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RU-SKI 43 hydrochloride

Name: RU-SKI 43 hydrochloride
Brand: TargetMol
SKU: T12797L
Rating: 4.5 (1 reviews)

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Catalog No. T12797LCas No. 1782573-67-4

RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat) with an IC50 of 850 nM and exhibits anti-cancer activity.

RU-SKI 43 hydrochloride

😃Good

Catalog No. T12797LCas No. 1782573-67-4

RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat) with an IC50 of 850 nM and exhibits anti-cancer activity.

Pack Size	Price	Availability	Quantity
2 mg	$73	5 days

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Product Introduction

Bioactivity

Description	RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat) with an IC50 of 850 nM and exhibits anti-cancer activity.
Targets&IC50	Hhat:850 nM
In vivo	After IV administration,RU-SKI 43 hydrochloride has a t1/2 of 17 min in mouse plasma[1].

Chemical Properties

Molecular Weight	423.01
Formula	C₂₂H₃₁ClN₂O₂S
Cas No.	1782573-67-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 51 mg/mL (120.56 mM)

H2O: 2.5 mg/mL (5.91 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3640 mL	11.8201 mL	23.6401 mL	118.2005 mL
5 mM	0.4728 mL	2.3640 mL	4.7280 mL	23.6401 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2364 mL	1.1820 mL	2.3640 mL	11.8201 mL
20 mM	0.1182 mL	0.5910 mL	1.1820 mL	5.9100 mL
50 mM	0.0473 mL	0.2364 mL	0.4728 mL	2.3640 mL
100 mM	0.0236 mL	0.1182 mL	0.2364 mL	1.1820 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RU-SKI 43 HydrochlorideRUSKI 43 hydrochlorideRU SKI 43 hydrochlorideHhat