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Rusfertide

Rusfertide
Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].
Catalog No. TP2618Cas No. 1628323-80-7

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Rusfertide

Catalog No. TP2618Alias PTG-300Cas No. 1628323-80-7

Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].
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Product Introduction

Bioactivity
Description
Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].
In vivo
Rusfertide reduces iron toxicity within red blood cells (RBCs) at a dosage of 1 mg/kg administered subcutaneously every two days for 49 days and decreases transferrin saturation at 2.5 mg/kg under the same administration schedule for two weeks. This enhances the oxygen-carrying capacity of RBCs and ameliorates anemia and iron accumulation in β-thalassemia and hereditary hemochromatosis mouse models [1]. Animal Model: Hbb th3/+ mice model for β-thalassemia and hereditary hemochromatosis [1] Dosage: 1 and 2.5 mg/kg Administration: s.c., once every two days, for 49 days (1 mg/kg); or for 2 weeks (2.5 mg/kg) Result: Improved the survival rate of RBCs in β-thalassemia model. Reduced transferrin-saturation and iron deposition.
AliasPTG-300
Chemical Properties
Molecular Weight2441.95
FormulaC114H181N27O28S2
Cas No.1628323-80-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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