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S 1924

Catalog No. T88868Cas No. 111371-30-3

S 1924 is an effective inhibitor of H+, K+-ATPase, exhibiting IC50 values of 10.3 μM at pH 7.4 and 1.6 μM at pH 6.0.

S 1924

S 1924

Catalog No. T88868Cas No. 111371-30-3
S 1924 is an effective inhibitor of H+, K+-ATPase, exhibiting IC50 values of 10.3 μM at pH 7.4 and 1.6 μM at pH 6.0.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
S 1924 is an effective inhibitor of H+, K+-ATPase, exhibiting IC50 values of 10.3 μM at pH 7.4 and 1.6 μM at pH 6.0.
In vitro
S 1924 inhibits histamine and dbc-AMP stimulated 14 C-aminopyrine uptake.
In vivo
S 1924, administered intravenously at a dose of 0.5 mg/kg, effectively inhibits gastric acid secretion in rats with gastric luminal perfusion stimulated by (gastrin-releasing peptide) (100 μg/kg/h, intravenous injection).
Chemical Properties
Molecular Weight277.37
FormulaC12H11N3OS2
Cas No.111371-30-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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