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SB-568849
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Catalog No. T16852Cas No. 395679-53-5
SB-568849 is an antagonist of the melanin-concentrating hormone receptor 1 (pKi: 7.7).
SB-568849
😃Good
Catalog No. T16852Cas No. 395679-53-5
SB-568849 is an antagonist of the melanin-concentrating hormone receptor 1 (pKi: 7.7).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 6-8 weeks | |
| 50 mg | $2,180 | 6-8 weeks | |
| 100 mg | $2,800 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB-568849 is an antagonist of the melanin-concentrating hormone receptor 1 (pKi: 7.7). |
| In vitro | SB-568849 is a selective SLC-1 antagonist (pKi: 7.7), as determined by radioligand binding displacement assays. Coincubation with SB-568849 (1 μM) for 45 minutes fully inhibits MCH-induced corticotropin-releasing factor (CRF) release, reducing it to basal levels without producing any effect on its own [2]. |
| In vivo | SB-568849 has good receptor affinity and selectivity. SB-568849 displays >30-fold selectivity over a wide range of monoamine receptors and is an antagonist in the FLIPR assay with a pKb of 7.7. SB-568849 retains affinity, demonstrates greater in vivo stability (CLb=16 mL/min/kg), and shows an acceptable brain-blood ratio of 1 [3]. |
| Molecular Weight | 500.55 |
| Formula | C28H31F3N2O3 |
| Cas No. | 395679-53-5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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