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SBP-0636457 (SB1-0636457) is a SMAC mimetic and IAP inhibitor that specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM, holding potential for research in solid tumors and hematologic cancers.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $996 | Backorder |
Description | SBP-0636457 (SB1-0636457) is a SMAC mimetic and IAP inhibitor that specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM, holding potential for research in solid tumors and hematologic cancers. |
Targets&IC50 | XIAP:0.27 μM (Ki) |
In vitro | SBP-0636457, at concentrations ranging from 1-20 μM, exhibits no cytotoxic effects on BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines, ensuring its safety up to a 20μM threshold[1]. Further, when administered at doses between 10-1000 nM for 20 hours, SBP-0636457 effectively enhances TRAIL-mediated apoptosis in MDA-MB-231 cells, achieving an EC50 of 9 nM, thus confirming its potency as a TRAIL-sensitizing agent[1]. |
Alias | SBP-0636457, SBI-0636457, SB1-0636457 |
Molecular Weight | 456.587 |
Formula | C25H36N4O4 |
Cas No. | 1422180-49-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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