SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1].

SCD1-IN-1 (compound I, 6 days) effectively inhibits SCD1 enzyme activity in intact human cells, with an IC50 of 6.8 nM [1].

SCD1-IN-1 (compound I, 1.5% w/v, 25 μL), applied to the ventral surfaces of both ears of the hamster ear model [1] at a dosage of 1.5% in a vehicle of propylene glycol/transcutanol/ethanol (20/20/60, w/v, 25 μL), twice daily for two weeks, significantly reduces cholesterol ester (CE) and wax ester (WE) production by 62% and 82%, respectively, indicating its effectiveness in modulating sebum production and sebaceous gland size in this model.