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SEC
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Catalog No. T36535Cas No. 1802997-81-4
SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
SEC
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Catalog No. T36535Cas No. 1802997-81-4
SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $297 | 6-8 weeks | |
| 25 mg | $985 | 6-8 weeks | |
| 50 mg | $1,280 | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2]. |
| In vitro | SEC (20 μM) inhibits the cell migration of HEK 293T RKIP-/- cells and PC3 prostate cancer cells[1].SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (cell selectively)[1]. Cell Viability Assay[1] Cell Line: HEK293T RKIP-/- cells.[1] |
| In vivo | SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in the PC-3M-Luc orthotopic implantation nude mice model[1]. Animal Model: Luciferase-labeled PC-3M-Luc cells (2×10^6 per 50 μL sterile HBSS-/-) are orthotopically inoculated into the prostates of 8-week-old nude mice[1]. |
| Molecular Weight | 430.88 |
| Formula | C22H23ClN2O5 |
| Cas No. | 1802997-81-4 |
| Relative Density. | 1.27 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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