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SEC

SEC
SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
Catalog No. T36535Cas No. 1802997-81-4
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SEC

Catalog No. T36535Cas No. 1802997-81-4
SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$2976-8 weeks
25 mg$9856-8 weeks
50 mg$1,2806-8 weeks
100 mg$1,8606-8 weeks
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Product Introduction

Bioactivity
Description
SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
In vitro
SEC (20 μM) inhibits the cell migration of HEK 293T RKIP-/- cells and PC3 prostate cancer cells[1].SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (cell selectively)[1]. Cell Viability Assay[1] Cell Line: HEK293T RKIP-/- cells.[1]
In vivo
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in the PC-3M-Luc orthotopic implantation nude mice model[1].

Animal Model: Luciferase-labeled PC-3M-Luc cells (2×10^6 per 50 μL sterile HBSS-/-) are orthotopically inoculated into the prostates of 8-week-old nude mice[1].
Chemical Properties
Molecular Weight430.88
FormulaC22H23ClN2O5
Cas No.1802997-81-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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